From Chattanooga TN

Approximately 2-1/2 hours.

Take I-75 north to US 64 (near Cleveland, TN). Drive east on US 64 (which becomes US 64/74) through Ducktown, TN and the Ocoee River Gorge into North Carolina. At Murphy, NC take US 19/74 east through Andrews, NC and the Nantahala Gorge to Cherokee (Exit 74).