From Charlotte NC

Approximately three hours.

Take I-85 west to US 74. Continue west on US 74 to I-26. Go north on I-26 to I-40. Take I-40 west to Exit 27 (US 74, the Great Smoky Mountains Expressway). Continue West on US 74 past Waynesville, Sylva and Dillsboro to Cherokee, Exit 74.