From Knoxville TN

You have a choice of four routes. Driving time depends on route and traffic.

1. Via Interstate 40 - Take I-40 east into North Carolina to exit 27 (US 74, the Great Smoky Mountains Expressway). Continue West on US 74 past Waynesville, Sylva and Dillsboro to Cherokee, Exit 74. The drive from Knoxville to Cherokee is approximately two hours.

2. Via Maryville and US 129 - Take US 129 south through Alcoa and Maryville. After crossing into North Carolina, take US 28 south to US 74 (the Great Smoky Mountains Expressway). Continue east on US 74 approximately 20 miles to Cherokee. Note: the section of US 129 known as "Deal's Gap" and "The Dragon" is extremely curvy (318 curves in 11 miles). The drive from Knoxville to Cherokee is approximately three hours

3. Via Pigeon Forge and the Great Smoky Mountains National Park - Take I-40 east to exit 407 and proceed south. At Sevierville, TN, take US 441 south through Pigeon Forge, Gatlinburg and the Great Smoky Mountains National Park to Cherokee, NC. Depending on traffic, the drive from Knoxville to Cherokee can be from two to three hours.

4. Via Townsend and the Great Smoky Mountains National Park - Take US 129 south through Alcoa to Maryville. In Maryville, take US 321 east to Townsend, TN. From Townsend, take Little River Road east through the Great Smoky Mountains National Park to US 441 (at the Park Visitors Center). Take US 441 south through the park to Cherokee. Depending on traffic, the drive from Knoxville to Cherokee is approximately three hours.